If you’re looking for the best vertical mouse for comfortable work sessions and boosted ergonomics, then you’ve come to the right place!

Here at WFHAdviser, we’ve featured some of the coolest vertical mice that may just match your budget, preferences, & purposes.

But first, let us tell you a little bit more about vertical mice. First of all, a typical horizontal mouse can’t maintain a healthy alignment between your arm and wrist. As a result, it may obstruct your blood circulation and cause fatigue, sprain, or twist.

But a vertical mouse allows you to maintain a natural handshake posture. Which is far healthier and stable for working and gaming. That’s why vertical mice are gaining popularity.

Most of the vertical mice come in a 6 button layout. In addition to the typical three, these mice have additional DPI adjustment, forward, & backward buttons. These extra buttons increase ease of access and give your mouse a more versatile role.

Moreover, vertical mice come in both wired and wireless variants. While the wireless ones give you comfortable access, they can run out of juice at an important moment. So the selection is completely up to you.

If you’re in the market for a mouse, you should also check out our article on full desk mouse pads to go along with it.

So without further ado, let’s take a look at the WFH recommendations.

As an affiliate partner, we may earn qualifying purchases made on products.

  • Wireless mouse
  • 6 button controls
  • Sleep mode

So on top of our list, we have the Kensington wireless vertical mouse. This mouse allows an ergonomic angle for your wrist, keeping it in a neutral handshake position. Such placement helps improve wrist and forearm posture & relieve soft tissue compression as well.

The mouse is 2.74 inches tall and 4.38 inches long. On top of the angled grip, the mouse has lip support for your little finger. Lets you experience more smooth and comfortable movements.

Moreover, this vertical mouse has 6 buttons. Alongside the left, right, and middle mouse buttons, there’s also a DPI control button. You can adjust your mouse accuracy with the following DPI settings; 800, 1200, 1600, 2000, 2400. And on the left side, you’ll find thumb controlled forward & backward buttons.

Furthermore, the mouse works remotely. You can go wireless with the 2.4GHz connectivity allowing 33 feet/10 meters range. A plug-and-play USB-A nano receiver comes with the mouse as well. When you’re not using the mouse, you can tuck the receiver inside the storage compartment.

Also, it has a very useful sleep function that saves battery while it’s idle.

  • Wireless
  • Up to 3 devices at once
  • Cross-device file transfer

As for our premium choice of this category, we recommend the cool-looking futuristic Logitech MX mouse. This mouse is also wireless. And it has really great polishing. Can be an excellent addition to your home and office.

The mouse has an ergonomic design that places your hand in a natural handshake position. And to do so, it uses a unique 57-degree angle. From different studies on the matter, it has been seen that this kind of placement prevents your forearm from twisting and reduces muscular strain by 10%.

Moreover, a typical mouse supports only around 1000 DPI. But the Logitech MX can reach up to 4000 DPI. That means 4x fewer hand movements. And what’s more? Using the Logitech FLOW, you can copy-paste files between three different devices at once. A great choice if you’re working on multiple devices.

You can go wireless with the USB Type-C unifying receiver. Control your devices from up to 10 meters away. Besides, the Type-C port can also recharge your mouse battery. It uses a 240 mAh lipo battery.

  • Ergonomic shape and design
  • Previous/next page buttons
  • Easily change mouse speed

There is a lot to like about this mouse. Its ergonomic design keeps your hand in the handshake position as opposed to clenched up on a normal mouse. It has built-in previous/next page buttons and a scroll wheel for easy navigation. It also comes standard with a DPI (Dots Per Inch) button to easily change the speed at which your mouse moves on screen. This mouse is also very affordable for all of its features. 

  • Unique design
  • 3 DPI levels
  • Dual connectivity

Our next recommendation is the Jelly Comb Bluetooth mouse. It offers up to 2.4 GHz wireless connectivity and 2400 DPI precision. Supports Bluetooth 4.0 as well.

The build is pretty unique. It features a concave area for resting your thumb. And there’s an extended bottom portion for keeping your little finger as well. So the grip is pretty effective and comfortable.

The Jelly Comb also ensures uninterrupted blood flow by maintaining a natural handshake posture for your hand & wrist. So you can work longer shifts without feeling tired or fatigued. Reduces strain and soreness.

Additionally, the mouse supports a 2.4 GHz wireless connection as well as a 4.0 Bluetooth connection. So you can freely switch between 2 devices simultaneously and get your work done even faster.

On top of working on different surfaces, the Jelly Comb wireless mouse supports 3 different DPI levels. The highest is 2400 DPI. Simply switch between different DPI options and find the speed and precision you’re comfortable with.

This widely compatible, elegant vertical mouse comes with a 12-months warranty as well.

  • Rechargeable
  • Wireless
  • 3 DPI modes

The LEKVEY vertical mouse has a sleek design like our budget recommendation. But instead of AAA batteries, it comes with rechargeable batteries.

The mouse has 3 DPI options. Starts from 800 DPI and supports up to 1600 DPI. Considering other competitive products on the market, it’s very smooth. Also, you can work on a variety of surfaces as it has standard optical features for smoother tracking.

Moreover, it has a 6 buttons design. Righ, left, middle wheel buttons as usual. There’s a DPI button on the top. Also on the left side, above the thumb, you’ll find a forward and a backward button. These buttons are useful for surfing the internet, reading a document, file, etc.

This mouse also ensures a natural handshake posture for your hand. Improves blood flow from hand to wrist. Reduces strain and soreness in the arm and lets you work longer shifts. Also no hassle of changing batteries. Recharge and reuse.

Moreover, the mouse is pretty much plug and play. While not is use, you can tuck in the wireless reciever into the dedicated slot.


  • Unconventional design
  • 3 DPI levels
  • Removable wrist-rest

The DELUX wireless vertical mouse is different from the above products. It has a far smoother appearance and ergonomic look that blends in with your work environment.

This unique vertical mouse comes with a special volute bionic design. Ensures better alignment between the arm & the wrist. As a result, you’ll experience better blood flow, reduced fatigue, and soreness.

Besides, the mouse has an unconventional design. The design finishing and polish are top-quality as well. It has a specially curved back, thumb groove, & well-distributed layout. Also, the grip and anti-skid properties boost ergonomics. 

Like similar mice, this one supports up to 1600 DPI sensitivity for better precision.

Similar to the previous wireless mice, it’s also plug and play. Supports up to 2.4 GHz wireless connection and connects from as much as 10m away. Also compatible with most OS versions.

Moreover, the mouse has a comfortable wrist-rest for working long shifts. However, if it’s not up to your likings, you can remove it.

Additionally, the company offers a 12 months warranty with this excellent product.

  • Dual RGB belts
  • 5 key Joystick
  • Wired mouse

The ZLOT vertical mouse is visibly different from the rest. It comes equipped with a 5 directional rocker that makes it easy to navigate front, rear, left, and right.

Similar to other products, this mouse maintains a natural handshake posture for your hand & wrist as well. Keeps your hand and wrist aligned for uninterrupted blood flow. Reduces strain, fatigue, and soreness.

Moreover, it has color-changing RGB marquee belts on both sides. Looks very cool and futuristic. Enhances your work environment quality. Besides, this high-quality mouse comes with 5 adjustable DPI levels. And it supports precision of up to 10000 DPI as well. Very useful if you’re looking for ultra-precision.

What’s more, instead of regular 6 buttons, this one has fully customizable 11 buttons. Use them to your advantage by putting some useful commands into them. Such versatility will surely come in handy while gaming. Though there’s one major difference. Unlike similar ergonomic mice, this one is wired like an old-fashioned model.  

And besides, it comes with a 1-year warranty as well. 

  • Wireless
  • up to 2400 DPI
  • 10 min auto-sleep

Next up, we have the VicTsing vertical mouse. This mouse is also wireless, supports 2.4 GHz connectivity, and up to 2400 DPI sensitivity.

The mouse has an ergonomic design that places your hand in a natural handshake position. And to do so, it uses a unique 54-degree angle. Aligns your hand and wrist. And this kind of placement prevents your forearm from twisting and reduces muscular strain by 10%.

Moreover, the mouse has 3 DPI options and the maximum can reach up to 2400 DPI. That means fewer hand movements for better precision. Besides, the building materials offer very good grip and stability. So you can keep using the mouse without any discomfort.

Similar to other wireless mice, you can simply plug and play with this one. Contains a nano controller at the bottom that sets up 2.4 GHz fast wireless connectivity.

This widely compatible mouse also features a sleep option. Automatically hibernates after 10 minutes of inactivity to greatly save battery life. Simply press any button to get it back to work.

  • Wired mouse
  • Optimized thumb rest
  • Programmable buttons

The Evoluent VM4R vertical mouse has a modified design. Compared to other vertical mice, it has an optimized thumb rest. Polished and comfort-oriented.

It has a typical 6 buttons design. The buttons carry the usual commands. However, it has a thoughtfully sculpted shape for maximum comfort. The buttons are easy-to-reach as well as programmable.

Another thing about the Evoluent VM4R is that it’s a wired mouse. So it may seem old fashioned. However, since it’s not dependent on a battery, it’ll never run out of power. So you won’t have to worry about power issues during an important meeting, presentation, or intense gaming session.

The Evoluent mouse also maintains a natural handshake posture. Ensures comfort for your hand & wrist. Align the joints at a healthy angle for uninterrupted blood flow. So work longer shifts or play non-stop without feeling tired or fatigued.

Besides, this wired mouse is compatible with different windows and mac versions. So you won’t have to worry about suitability issues and other trivial things.

  • Up to 50 ft range
  • Whisper quiet click
  • Economical

And last but not least, we feature the iClever vertical mouse. This mouse has a compact ergonomic build to match your profession and preferences. It has 4 DPI levels alongside some pretty cool features. But what makes it stand out from the crowd is its superbly affordable price.

The mouse has a thoughtful design that promotes ergonomics. With power-users in mind, it was precisely shaped to relieve your wrist of fatigue, pains, and crampings. Moreover, it features side grips, a thumb rest, and strategically placed buttons for better access and operations.

Even though the mouse has a budget build, it has 4 precision levels. One of them being 2400 DPI which is pretty high compared to other competitive products. And besides, the 6 buttons design boosts ease of access. Letting you work, browse, read, or play like never before.

Also, the iClever mouse supports up to 2.4 GHz connectivity. With the powerful receiver, you can control your device from as much as 50ft away. Besides, the whisper-quiet click technology allows you to work without disturbing your family members and co-workers.

Vertical Mouse Buyer’s Guide

Nowadays, there are many alternatives to the conventional mouse for your computer. For example, you can have a vertical mouse or even a trackball mouse. The evolution of the vertical mouse has altered the way we thought about a typical computer mouse. Besides being an important functional unit, vertical mice are ergonomic, and comfortable.

You should get a vertical mouse today to reduce the chances of developing wrist problems. If you spend hours on your computer and are beginning to suffer from wrist pain, then you need to find the best vertical mouse for you. Vertical mice are engineered primarily to decrease the activity of your wrist, shifting the effort to your arm muscles instead.

Best Vertical Mouse Features

It’s Comfortable

The goal of buying a vertical mouse is to make it more convenient than a regular mouse. Not to mention if you have carpal tunnel syndrome. Each model has been built differently, so it can vary in the degree of comfort for users. Keep in mind that it will take you a while to get used to the new form if you have not used a vertical mouse before, so it is best to continue using it for a week or so before you begin to experience the advantages.

DPI Switch

A DPI (dots per inch) switch allows you to change the sensitivity of your mouse to motion. This ensures that you can, at the click of a button, change the speed of the mouse’s motions. Some of the better vertical mouse options include a button, which adjusts the accuracy settings with a short click so that it can move quicker or smoother. Normally, with a traditional mouse you would have to change your mouse’s sensitivity by going through several steps in the control panel.

High DPI is perfect if your tasks require more speed than precision, like web surfing. However, if you have to lower sensitivity for gaming or photo editing, you will appreciate having a DPI switch.

Left/Right-Handed Vertical Mouse

The majority of vertical mice are developed for right-handed people to use. There are, however, a few manufacturers that explicitly produce versions for left-handed people. If you use either hand easily, then this is good for you. However, you can find a left-handed model if you need to stop using your right hand to alleviate discomfort, but your choices are more limited.


If it comes to the number of keys, there is no ‘right’ option; it is a personal choice. Where they are situated is something you should remember. There are thumb pads, buttons on the side, right next to the scroll wheel in some vertical mouse versions. It’s up to you which is the best.

The basic left and right pads, a scroll wheel, and a website forward/backward control are still the most common features on vertical mice. Sometimes there may be an additional button or two, but the most significant selling point is their customization. You can configure each button using the included software to be a shortcut of your choosing.


For maximum comfort, a vertical mouse should match your hand comfortably. When it comes to mice, one size does not suit everyone. You can probably find one with dimensions that fit right in your hand. Several of the best vertical mouse contenders come in various sizes.

From the product feedback, you can note that certain vertical mice are listed as unsuitable for big or tiny paws. The easiest way to determine whether a new mouse is going to work for you is to check the measurements and match it to a device you’re currently using. This should have an estimated indicator for you.


An ergonomic mouse‘s weight will decide how easy it is to use. The heavier it is, the more your muscles will have to act, which will make the signs of pain greater. If you use your mouse for games, this is particularly true. There’s a large range for vertical mice, but the best vertical mouse comes around the 100g mark.

Wireless vs Wired Vertical Mouse

Wired mice have benefits and drawbacks. For starters, You don’t need to think about batteries being charged or interrupting communications. You do have to compete, though, with wires getting in the way and potentially becoming intertwined, especially when playing games. You get more flexibility and mobility from a wireless mouse, but you will need to make sure it is charged.